Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking

نویسندگان

  • Pirus Ghadjar
  • Jacqueline Vock
  • Daniel Vetterli
  • Peter Manser
  • Roland Bigler
  • Jan Tille
  • Axel Madlung
  • Frank Behrensmeier
  • Roberto Mini
  • Daniel M Aebersold
چکیده

BACKGROUND To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking. METHODS From 06/2004 to 12/2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy (HT) was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up (FU) was 29 months. RESULTS Acute and maximal late grade 2 gastrointestinal (GI) toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary (GU) morbidity (PGUM) was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late > or = grade 2 GU toxicity free survival was associated with higher age (P = .025), absence of HT (P = .016) and higher PGUM (P < .001). DISCUSSION GI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.

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عنوان ژورنال:
  • Radiation Oncology (London, England)

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2008